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The Prognostic Value of G1 Cyclins, p21 and Rb Protein in Patients With Colon Cancer.

By: Pantelis Palaiologos, Dimosthenis Chrysikos, Stamatios Theocharis, Gregory Kouraklis

2nd Department of Propedeutic Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
2019-07-08; doi: 10.21873/anticanres.13839

Abstract

Background/aim

Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation.

Patients

A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry.

Results

Levels of cyclin E expression were correlated with cyclin D1 expression (p=0.038), p21 expression (p=0.047), and pRb expression (p=0.004). The 5-year survival rate along with prognosis of patients with advanced stage (III, IV) colon cancer and cyclin D1 positive tumors, were significantly worse (p=0.009). Statistically significant association was observed between tumor proliferative capacity Ki-67, cyclin D1 (p=0.009), pRb (p=0.031) and p21 (p=0.050).

Conclusion

Cyclin D1 is highly expressed in advanced stage colon cancer patients, implying a potential prognostic value.