ONCOmmunity

Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy.

By: Taichi Matsubara, Fumihiko Hirai, Masafumi Yamaguchi, Motoharu Hamatake

Department of Thoracic Surgery, Kitakyushu Municipal Medical Center, Fukuoka, Japan taichi.m0930@gmail.com.
2021-07-07; doi: 10.21873/anticanres.15333

Abstract

Background/aim

Adjuvant platinum-based chemotherapy (APC) has been the standard of care for patients with non-small-cell lung cancer (NSCLC) who have undergone complete pulmonary resection. This study analyzed the clinical and prognostic significance of immunonutritional indices in NSCLC patients receiving APC.

Patients

We retrospectively reviewed 110 patients from 2008 to 2016. Three immunonutritional indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI).

Results

The median age was 64 years, and 66 patients were males. Each index showed a significant correlation with primary tumor length. NLR and PLR were significantly correlated with vascular invasion. Prognostic analyses revealed that each index was significantly correlated with postoperative recurrence-free survival (RFS) and overall survival (OS). On multivariate analyses, PNI was an independent predictor of RFS and OS.

Conclusion

Host immunonutritional status may have a significant effect on the postoperative prognosis of NSCLC in patients receiving APC.