Associations between Autoimmune Conditions and Gastric Cancer Risk among Elderly Adults in the United States.
By: Minkyo Song, M Constanza Camargo, Andriy Derkach, Charles S Rabkin, Eric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
2021-07-26; doi: 10.14309/ajg.0000000000001622
2021-07-26; doi: 10.14309/ajg.0000000000001622
Abstract
Introduction
Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute.
Methods
In a case-control study, we evaluated 47 autoimmune conditions among 35,499 gastric cancers and 200,000 cancer-free controls.
Results
Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios [ORs]: 1.28-1.93, p<0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves' disease. PA was associated with 8 other autoimmune conditions (adjusted ORs: 1.57-4.54, p<0.05).
Conclusions
Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
Copyright © 2022 by The American College of Gastroenterology.
PMID:35029169
