MACC1 as a marker for advanced colorectal carcinoma
By: Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K.
Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.
Anticancer Res. 2010 Jul; 30(7):2689-92.
Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.
Anticancer Res. 2010 Jul; 30(7):2689-92.
Abstract
Background
Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases.
Patients and methods
We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR).
Results
We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007).
Conclusion
These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.
PMID: 20682999 [PubMed - indexed for MEDLINE] Source: National Library of Medicine.
