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GNAO1: A Novel Tumor Suppressor Gene in Colorectal Cancer Pathogenesis.

By: Hong-Beum Kim, Woo Young Choi, Seong-Hun Kim, Hee-Jeong Lee, Sang-Gon Park

Department of Premedical Course, Chosun University School of Medicine, Gwangju, Republic of Korea.
2024-10-25; doi: 10.21873/anticanres.17368

Abstract

Background/aim

This study examined the role of GNAO1 as a potential tumor suppressor gene in colorectal cancer (CRC).

Materials

RNA-seq data analysis revealed a significant GNAO1 down-regulation in colon cancer tissues compared to normal colon tissues.

Results

GNAO1 over-expression in CRC cell lines inhibited cell proliferation, migration, and tumor formation both in vitro and in vivo. This study suggests that GNAO1 exerts its tumor-suppressive effects by inhibiting the mTOR/S6K signaling pathway. The observed correlation between GNAO1 expression and cancer progression highlights its potential as a prognostic marker and therapeutic target in CRC.

Conclusion

This study provides a foundation for further exploration of the molecular mechanisms by which GNAO1 influences CRC pathogenesis, with significant implications for its application in clinical settings.