ONCOmmunity

Methylation of the TFPI2 Gene Is Frequently Detected in Advanced Gastric Carcinoma

By: Hibi K, Goto T, Kitamura YH, Sakuraba K, Shirahata A, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.

Department of Surgery, Showa University Fujigaoka Hospital, Aoba-ku, Yokohama, Japan. kenjih-ngy@umin.ac.jp
Anticancer Res. 2010 Oct; 30(10):4131-3.

Abstract

Background

Recently, Glockner et al. identified the methylation of TFPI2 as a frequent event in human colorectal cancer using a gene expression array-based strategy.

Materials and methods

Methylation status of the TFPI2 gene was examined in primary carcinomas and the corresponding normal tissues derived from 38 patients with gastric cancer using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated.

Results

Aberrant methylation of the TFPI2 gene was detected in 7 out of 38 (18%) primary gastric carcinomas, suggesting that the methylation of TFPI2 is frequently observed in gastric carcinomas. The clinicopathological data were correlated with the methylation results. A significant difference was observed in maximal tumour size (p=0.0084), extent of tumour (p=0.0068), and TNM stage (p=0.0392).

Conclusion

TFPI2 is frequently methylated in advanced gastric carcinomas.

PMID: 21036731 [PubMed - in process] Source: National Library of Medicine.