Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells
By: Martin-Orozco N, Li Y, Wang Y, Liu S, Hwu P, Liu YJ, Dong C, Radvanyi L.
Authors' Affiliations: Departments of Immunology and Melanoma Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas.
Cancer Res. 2010 Nov 23.
Authors' Affiliations: Departments of Immunology and Melanoma Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas.
Cancer Res. 2010 Nov 23.
Abstract
CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion. Cancer Res; 70(23); 1-10. ©2010 AACR.
PMID: 21098714 [PubMed - as supplied by publisher] Source: National Library of Medicine.
