ONCOmmunity

Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients

By: Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO, Nicolai P.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy. g.peretti@tin.it
Head Neck. 2010 Aug; 32(8):977-83.

Abstract

Background

Transoral CO(2) laser surgery has been accepted as a valuable therapeutic option for glottic cancer.

Methods

This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.

Results

Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re-treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re-treatment on local control with laser and organ preservation.

Conclusion

This series confirms the good oncologic outcomes of endoscopic laser surgery for T(is), T(1), and selected T(2) and T(3) glottic tumors.

2009 Wiley Periodicals, Inc. Head Neck, 2010.

PMID: 19902535 [PubMed - indexed for MEDLINE] Source: National Library of Medicine.