ONCOmmunity

Down-regulation of Mus81 as a Potential Marker for the Malignancy of Gastric Cancer

By: Wu F, Shirahata A, Sakuraba K, Kitamura Y, Goto T, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K.

Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan. kenjih-ngy@umin.ac.jp.
Anticancer Res. 2010 Dec; 30(12):5011-4.

Abstract

Background

The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored.

Materials and methods

Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated.

Results

Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p=0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p=0.015) and poorly-differentiated type (p=0.016) of gastric cancer.

Conclusion

Mus81 might be a potential marker for the malignancy of gastric cancer.

PMID: 21187482 [PubMed - in process] Source: National Library of Medicine.