[1] Gene Signal Research Center, 4 Rue Pierre Fontaine, Evry 91000, France [2] Groupe de recherche MERCI (EA 3829), Faculté de Médecine & Pharmacie, Rouen 76000, France.
Br J Cancer. 2011 Jan 4.
Loss of CD9 is inversely related to the expression of CD9P-1, which correlates with the metastatic status of hLT (n=55). In vitro, GS-168AT2 is rapidly internalised and degraded at both the membrane and cytoplasm of NCI-H460, and this correlates with the association of GS-168AT2 with both CD9 and CD81. Intraperitoneal injections of GS-168AT2 in NCI-H460-xenografted Nude mice led to drastic inhibition of tumour growth, as well as to the downregulation of CD9, but not of CD81, in the tumour core.
These findings show for the first time that CD9P-1 expression positively correlates with the metastatic status of hLT, and that the upregulation of CD9P-1 expression could be one of the mechanisms underlying the loss of CD9 in solid tumours. Our study also reveals that, under certain conditions, loss of CD9 could be a tumour growth-limiting phenomenon rather than a tumour growth-promoting one.
British Journal of Cancer advance online publication, 4 January 2011; doi:10.1038/sj.bjc.6606033 www.bjcancer.com.
PMID: 21206492 [PubMed - as supplied by publisher] Source: National Library of Medicine.
