ONCOmmunity

TIP60 as a Potential Marker for the Malignancy of Gastric Cancer

By: Sakuraba K, Yokomizo K, Shirahata A, Goto T, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K.

Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan. kenjih-ngy@umin.ac.jp.
Anticancer Res. 2011 Jan; 31(1):77-9.

Abstract

Background

Recently, it has been shown that the loss of the human histone acetyl transferase, TIP60, led to an accumulation of double-strand DNA breaks and has been linked to a growing number of cancer types.

Materials and methods

TIP60 expression levels were examined in 46 gastric cancer samples using a quantitative real-time polymerase chain reaction (QRT-PCR). Subsequently, clinicopathological data were correlated with the TIP60 expression score.

Results

A down-regulation of the TIP60 gene was observed in 28 out of 46 (61%) specimens of primary gastric cancer. TIP60 down-regulation showed significant correlation with patient age (p=0.0224), depth of tumor invasion (p=0.0401) and lymph node metastasis (p=0.0481).

Conclusion

The down-regulation of TIP60 is important for the malignant pathway of gastric carcinogenesis.

PMID: 21273583 [PubMed - in process] Source: National Library of Medicine.