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Association of polymorphisms and haplotypes of the NBN gene with laryngeal cancer and multiple primary tumors of the head and neck

By: Ziółkowska-Suchanek I, Mosor M, Wierzbicka M, Fichna M, Rydzanicz M, Nowak J.

Department of Molecular Pathology, Institute of Human Genetics of the Polish Academy of Sciences, Strzeszyńska 32 St., 60-479 Poznań, Poland. iwziol@man.poznan.pl.
Head Neck. 2011 Apr 5. doi: 10.1002/hed.21741.

Abstract

Background

We investigated whether genetic polymorphisms of the DNA repair gene NBN are associated with head and neck cancer risk.

Methods

We analyzed 6 polymorphisms in 175 patients with a single laryngeal tumor, 104 with multiple primary tumors but 1 malignancy (primary/second) localized in the larynx, 60 patients with multiple primary tumors localized in the head or neck, and 275 controls.

Results

Although frequencies of single nucleotide polymorphism alleles did not show marked differences, we found significant differences in haplotype frequencies between patients and controls. Haplotypes GGTTAA and ACCCGT were associated with an increased risk of laryngeal cancer (p < .0001, p = .002) and haplotypes GGCCAA and GCCCGT with an increased risk of multiple primary tumors (p < .0001, p = .039).

Conclusion

Specific haplotypes of the NBN gene may be related to increased susceptibility to laryngeal cancer and second primary tumors localized in the head and neck. © 2011 Wiley Periodicals, Inc. Head Neck, 2011.

PMID: 21472885 [PubMed - as supplied by publisher] Source: National Library of Medicine.