ONCOmmunity

Hormonal contraceptives and the length of their use are not independent risk factors for high-risk HPV infections or high-grade CIN

By: Longatto-Filho A, Hammes LS, Sarian LO, Roteli-Martins C, Derchain SF, Eržen M, Branca M, Tatti S, Naud P, de Matos JC, Gontijo R, Maeda MY, Lima T, Costa S, Syrjänen S, Syrjänen K.

Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal. longatto@ecsaude.uminho.pt
Gynecol Obstet Invest. 2011; 71(2):93-103. Epub 2010 Dec 9.

Abstract

Aims

To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study.

Methods

A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC - oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+.

Results

HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions.

Conclusions

No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.

PMID: 21150159 [PubMed - indexed for MEDLINE] Source: National Library of Medicine.