ONCOmmunity

The expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas

By: Takeyama H, Kyoda S, Okamoto T, Manome Y, Watanabe M, Kinoshita S, Uchida K, Sakamoto A, Morikawa T.

Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan. takeyama@jikei.ac.jp
Anticancer Res. 2011 Apr; 31(4):1395-8.

Abstract

Background

Papillary thyroid carcinoma (PTC) is often accompanied by lymph node metastasis (LNM), compared with follicular thyroid carcinoma (FTC). Sialic acid is carried by fibronectin (sFN) as the antigen of monoclonal antibody (MoAb) JT-95 detected in 90% of PTC, and a few cases of FTC.

Patients And Methods

JT-95 staining was performed in 9 PTC and 20 follicular type tumors to investigate the relationship between the expression of sFN and the frequency of LNM.

Results

There were 11 cases with LNM from 23 malignant tumors, and no cases of LNM from 6 benign follicular type tumors. The staining scores by JT-95 of the 11 tumors with LNM were 5+ in 4 cases, and 6+ in 7 cases. On the other hand, the scores of 12 malignant tumors without LNM were <4+ in all cases.

Conclusion

An increase of sFN expression in thyroid malignancies is correlated with LNM.

PMID: 21508391 [PubMed - indexed for MEDLINE] Source: National Library of Medicine.