ONCOmmunity

Expression of IGF-1 and IGF-1R and Their Relation to Clinicopathological Factors in Colorectal Cancer

By: Shiratsuchi I, Akagi Y, Kawahara A, Kinugasa T, Romeo K, Yoshida T, Ryu Y, Gotanda Y, Kage M, Shirouzu K.

Department of Surgery, Faculty of Medicine, Kurume University, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan. ichitaro1217@yahoo.co.jp.
Anticancer Res. 2011 Jul; 31(7):2541-5.

Abstract

Background

Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer.

Patients and Methods

A prospective study was conducted of 210 colorectal cancer patients that underwent resection from January 2002 to December 2004. The clinicopathological data was correlated to expression of IGF-1 and IGF-1R obtained from immunohistochemical analysis. Statistical analysis was carried using univariate and multivariate analysis.

Results

IGF1 and IGF-1R staining was positive in 169 (80%) and 139 (66%) cases, respectively. Univariate and multivariate analyses showed significant correlation between expression of IGF-1 and tumor size (p=0.0024), and depth of invasion (p=0.0147). While IGF-1R was significantly correlated to tumor size and depth of invasion in univariate analysis, only tumor size (p=0.0658) had a strong association in multivariate analysis.

Conclusion

Expression of IGF-1 and IGF-1R seems to increase with tumor size in colorectal cancer.

PMID: 21873172 Source: National Library of Medicine.