MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins
By: Chen H, Lin YW, Mao YQ, Wu J, Liu YF, Zheng XY, Xie LP.
Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Cancer Lett. 2012 Jan 20.
Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Cancer Lett. 2012 Jan 20.
Abstract
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of T24 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer.
Copyright © 2012. Published by Elsevier Ireland Ltd.
PMID: 22266187 [PubMed - as supplied by publisher] Source: National Library of Medicine.
