ONCOmmunity

TLR4 and NOD2/CARD15 Genetic Polymorphisms and their Possible Role in Gastric Carcinogenesis

By: Rigoli L, Di Bella C, Fedele F, Procopio V, Amorini M, Lo Giudice G, Romeo P, Pugliatti F, Finocchiaro G, Lucianò R, Caruso RA.

Department of Pediatrics, Messina University, Italy
Anticancer Res. 2010 Feb; 30(2):513−7.

Abstract

Aim

The aim of this study was to evaluate the role of TLR4 and NOD2/CARD15 genes in gastric carcinogenesis.

Patients And Methods

We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD15 (R702W, G908R, and L1007finsC) SNPs in 87 asymptomatic serologically H. pylori−positive individuals (Group I), in 63 patients with antrum−predominant gastritis (Group II) and in 60 patients with corpus−predominant gastritis or pangastritis (Group III).

Results

There was significant difference in allelic frequencies of TLR4 D299G SNP in Group II (p=0.02; OR 2.97) as well as in Group III (p=0.001; OR 4.80). Significant difference of T399I SNP allele frequency was only found in Group III (p=0.009; OR 3.73). The allele frequencies of NOD2/CARD15 G908R and of L1007insC SNP were higher in Group III (p=0.003, OR 5.18; p=0.03; OR 3.66, respectively).

Conclusion

TLR4 and NOD2/CARD15 genes are associated with high risk Group III patients and, therefore, they appear to play a role in gastric carcinogenesis.

PMID: 20332463 [PubMed − in process] Source: National Library of Medicine.

* Albert Einstein College of Medicine has been
awarded Acceditation with Commendation by
the ACCME