Women's College Research Institute, Women's College Hospital, 790 Bay Street, 7th Floor, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Health Science Building, 6th Floor, Toronto, ON, Canada.
Gynecol Oncol. 2012 Jun 16.
Ovarian cancer is a highly fatal gynecologic malignancy. Prognosis is primarily based on clinicopathologic features. There is interest in the role of modifiable factors including overweight and obesity, although data to-date have been inconclusive. Here we evaluate the relationship between body size and ovarian cancer survival among 1,423 women diagnosed with epithelial ovarian cancer in a large population-based study.
Information on risk factors and characteristics was collected by telephone. Vital status was determined both by computerized record-linkage and by chart review. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for height, weight and body mass index (BMI) in association with ovarian cancer-specific mortality.
Height, weight and BMI five years prior to diagnosis did not significantly predict ovarian cancer survival in this study. The HR for ovarian cancer-specific mortality for women with a weight of >61kg compared with >50 - 55kg was 0.91 (95%CI 0.71-1.20). The HR among women with a BMI≥30kg/m(2) compared to 18.5-<25kg/m(2) was 1.11 (95%CI 0.87-1.42). These findings did not vary by histologic subtype.
Our results do not support a role of height, adult weight or adiposity in ovarian cancer prognosis.
Copyright © 2012 Elsevier Inc. All rights reserved.
PMID: 22713293 [PubMed - as supplied by publisher] Source: National Library of Medicine.
