Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5
By: El-Haibi, Christelle P, Sharma, Praveen, Singh, Rajesh, Gupta, Pranav, Taub, Dennis D, Singh, Shailesh, Lillard,, James W
BioMed Central Ltd
2013-06-18; doi: 10.1186/1476-4598-12-64
BioMed Central Ltd
2013-06-18; doi: 10.1186/1476-4598-12-64
Abstract
Background
Prostate cancer (PCa) cell lines and tissues differentially express CXCR5, which positively correlate with PCa progression, and mediate PCa cell migration and invasion following interaction with CXCL13. However, the differential expression of G protein alpha, beta, and gamma subunits by PCa cell lines and the precise combination of these proteins with CXCR5 has not been elucidated
Conclusions
These findings offer insight into molecular mechanisms of PCa progression and can help to design some therapeutic strategies involving CXCR5 and/or CXCL13 blockade and specific G protein inhibition to abrogate PCa metastasis.
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