Applied Molecular Biology Research Group (AMBIOR), Laboratory of Cell Biology and Histology, University of Antwerp Laboratory for Clinical Pathology (Labo Lokeren − Campus Riatol) Translational Cancer Research Group (Laboratory of Pathology, University of Antwerp/University Hospital Antwerp, Oncology Center, General Hospital St. Augustinus), Antwerp Department of Obstetrics and Gynecology, Surgical Gynecologic Oncology Unit, Liege, Belgium Research Institute of Oncology (IPON), Gynecology and Obstetrics Research Institute of Oncology (IPON), Immunology, Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil Department of Obstetrics and Gynecology, Surgical Gynecologic Oncology Unit, Geneva University Hospitals, Geneva, Switzerland.
Eur J Cancer Prev. 2010 Jan 22.
The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer.
PMID: 20101182 [PubMed − as supplied by publisher] Source: National Library of Medicine.
