Pregnancy increases the growth rates of World Health Organization grade II gliomas
By: Pallud J, Mandonnet E, Deroulers C, Fontaine D, Badoual M, Capelle L, Guillet-May F, Page P, Peruzzi P, Jouanneau E, Frenay M, Cartalat-Carel S, Duffau H, Taillandier L; Club de Neuro-Oncologie de la Société Française de Neurochirurgie (SFNC); Association des Neuro-Oncologues d'Expression Française (ANOCEF).
Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France. johanpallud@hotmail.com
Ann Neurol. 2010 Mar; 67(3):398-404.
Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France. johanpallud@hotmail.com
Ann Neurol. 2010 Mar; 67(3):398-404.
Abstract
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.
PMID: 20373352 [PubMed - in process] Source: National Library of Medicine.
