T-Cell Dysfunction In CLL Is Also Mediated By PD-1/PD-L2 Interactions -- Partial Functionality Is Maintained In PD-1 Defined CD8 Subsets and This Can Be Further Promoted By Ibrutinib Treatment
McClanahan F, Miller S, Riches JC, et al.
Key Points:
PD-L2 expression is a unique feature of CLL cells
Also mediates T-cell dysfunction in CLL
Interaction between PD-L2 on CLL cells and its cognate receptor PD-1 on T-cells was characterized by impaired proliferation of T-cells, failure to localize granzyme B to the immunological synapse, and diminished elaboration of cytokines such as TNFα, IL2 and IFNγ
Partial reversal of T-cell dysfunction was achieved with treatment with ibrutinib
Implications:
- Modulation of PD-1/PD-L2 may represent another therapeutic strategy in CLL patients
View the original abstract on the ASH website.
