Signal Transducer and Activator Of Transcription 3 Activates and Deregulates Micro RNA Expression In Chronic Lymphocytic Leukemia Cells
Uri R, Calin G, Setoyama T, et al.
Key Points:
Mechanisms by which STAT3 regulates levels of expression of microRNA (miR)genes in CLL reported
Experiments conducted by authors showed that STAT3 downregulated the levels of expression of 63 miR genes critical for CLL tumorigenesis including miR-15, miR-16, miR-21 and miR-155
Control of miR genes expression by STAT3 largely mediated by regulating transcription by binding to miR promoter sequences
Implications:
- Data confirmed that STAT3 is a regulator of miR genes expression levels in CLL
View the original abstract on the ASH website.
