CD49d Is The Strongest Flow Cytometry-Based Predictor Of Overall Survival In Chronic Lymphocytic Leukemia
Bulian P, Shanafelt TD, Fegan C, et al.
Key Points:
Impact of CD49d as independent prognostic predictor of poor overall survival (OS) and treatment free survival (TFS) in chronic lymphocytic leukemia(CLL) patients evaluated
Using flow-cytometry-based experiments, disease considered CD49d positive if ≥30% of neoplastic cells expressed the protein
CD49d positivity strongly confers poor TFS and OS rates
Implications:
- CD49d expression by flow cytometry may represent strongest predictor of outcomes in CLL patients
Additional Comments:
Additional validation warranted before adoption in clinical practice.
View the original abstract on the ASH website.
