Externally Validated Predictive Clinical Model For Untreated Del(17p13.1) Chronic Lymphocytic Leukemia Patients
Stephens DM, Stark A, Wierda WG, et al.
Key Points:
Retrospective review of treatment-naive CLL patients with 17p- to identify subgroup at high risk of early death using simplified scoring systems developed by authors
Simplified risk score (SRS) for predicting treatment free survival (TFS) included clinical characteristics, e.g., age, ECOG PS, Rai Stage, WBC and 11q- with possible scores ranging from 0 to 7. SRS scores of 0/1, 2/3, and >4 correlated with 2-year TFS estimates of 85%, 51%, and 0% respectively
SRS for predicting OS rates also developed
Implications:
- Novel scoring systems can be utilized to guide treatment decision making process in treatment-naive CLL patients
View the original abstract on the ASH website.
