A Canadian Blood and Marrow Transplant Group (CBMTG) Randomised Trial Comparing G-CSF Mobilized Peripheral Blood Versus G-CSF Stimulated Bone Marrow In Recipients Of Sibling Allografts For Hematologic Malignancies
Couban S, Aljurf M, Lachance S, et al.
Key Points:
G-CSF stimulated marrow (G-BM) allografts may lead to faster hematological recovery and less severe chronic GvHD compared with G-CSF mobilized peripheral blood (G-PB)allografts
Results of randomised trial of matched sibling G-PB vs G-BM allografts in adults with hematologic malignancies reported
Neutrophil and platelet recovery slower with G-BM
Non-significant trends of less acute and less extensive cGvHD with G-BM observed
Implications:
- G-BM allografts did not confer any survival advantage
View the original abstract on the ASH website.
