A Systematic Search Into The Role Of IGHV Gene Replacement In Shaping The Immunoglobulin Repertoire Of Chronic Lymphocytic Leukemia
Yancopoulos S, Yan X, Agathangelidis A, et al.
Key Points:
Immunoglobulin heavy variable (IGHV) gene replacement may represent process whereby unwanted autoreactive antibodies eliminated by normal B-cells and CLL cells
Compared with normal B-cells, IGHV rearrangements occur at slightly higher frequency according to results of experiments
Higher rates of IGHV replacements seen in certain CLL subgroups including M-CLL, ZAP-70-neg, CD38-neg, 13q del, and non-stereotyped
Implications:
IGHV rearrangements may represent mechanism by which certain CLL subsets are less responsive to antigen-drive and autoreactivity
View the original abstract on the ASH website.
