Modulation of B Cell Receptor Signalling By IL-4 In Chronic Lymphocytic Leukaemia
Aguilar-Hernandez M, Blunt MD, Strefford JC, et al.
Key Points:
In vitro studies have shown that IL-4 rescue CLL cells from apoptosis, but exact mechanisms unknown
Authors report that IL-4 amplified conventional BCR mediated signalling in CLL cells by increasing sIgM receptor density
Amplified BCR signaling associated with high levels of expression of phosphorylated ERK (ERK-P)
Implications:
- Multiple inputs from microenvironment converge on BCR signalling to promote tumor development and progression in CLL
View the original abstract on the ASH website.
