IGHV Mutation Status Does Not Add Prognostic Information In The Background Of Mutations In TP53 and SF3B1, and Deletions Of 17p and 11q, Which Are Independent Adverse Prognostic Parameters In CLL
Haferlach C, Jeromin S, Weissmann S, et al.
Key Points:
Unmutated IGHV status established as independent poor prognostic marker in CLL
Recent studies by authors showed that unmutated IGHV status associated with other several adverse prognostic markers (TP53mut, SF3B1mut, NOTCH1, del(17p), del(11q))
Independent prognostic impact of unmutated IGHV status lost in the background of some of these genetic lesions
Implications:
- Data confirm previously reported impact of IGHV mutational status on survival and its associations with other genetic lesions
