Whole Exome Sequencing Of Multiple Myeloma Reveals An Heterogeneous Clonal Architecture and Genomic Evolution
Bolli N, Avet-Loiseau H, Wedge D, et al.
Key Points:
Using novel molecular technologies, genomic event underlying MM pathogenesis investigated
MM found to be heterogeneous at time of diagnosis, with mutations of known driver genes being subclonal
Several new recurrent genetic lesions also identified
Epigenomic aberrations and chromosomal copy-number changes also contribute to pathogenesis
Implications:
- Identification of molecular alterations associated with transformation and progression in MM may provide additional insights into mechanisms of drug-resistance in MM
View the original abstract on the ASH website.
