Both PI3K p110α and p110δ Isoforms Control CD160-Mediated CLL Cell Viability and Cytokine Production
Farren TW, Liu F, Agrawal SG
Key Points:
In this abstract, authors report on signaling pathway of CD160-mediated CLL cell viability
CD160 preferentially expressed by malignant B-cells of CLL, and confers increased cell viability, self-sufficient in growth signaling, and marked cytokine production
CD160 signaling associated with activation of lipid kinases PI3K p110α and p110d catalytic subunits and their downstream effector molecules
Implications:
- Targeting CD160 may represent novel treatment strategy in CLL patients
View the original abstract on the ASH website.
