Characterization Of a Novel In Vitro Circulation System Designed To Model The Migration Of Primary CLL Cells Across The Vascular Endothelium
Walsby EJ, Buggins A, Devereux S, et al.
Key Points:
Authors developed in-vitro model to characterize and explore molecular mechanisms underlying lymphocyte trafficking across vascular endothelium in CLL
Transmigration into extravascular space by CLL cells an active process
Degree of migration strongly correlated with CD49d, MMP-9, CD38, CD80, and CD69 expression
Treatment with Natalizumab, a CD49d blocking antibody, resulted in significant decreased migration
Implications:
- CD49d plays critical role in CLL cell migration, and may serve as novel attractive target for anti-cancer therapy in CLL
View the original abstract on the ASH website.
