Trisomy 12 CLL Cells Have High Surface Expression Of Integrins Involved In Lymphocyte Trafficking But This Does Not Translate Into Improved LFA-1-Mediated Motility
O'Donovan CJ, Ramsay AG, McClanahan F, et al.
Key Points:
The authors report levels of expression of integrins in trisomy 12 CLL cells compared with non-trisomy 12 CLL cells, and their prognostic implications
In comparison with non-trisomy 12 patients, CLL cells from patients with trisomy 12 demonstrated increased expression levels of integrins including CD11a, CD11b, CD18, CD29 and CD49d
Increased integrins expression in trisomy 12 CLL cells did not translate into cell motility
Implications:
- Additional studies warranted to determine functional biology of high integrins expression by trisomy 12 CLL cells
View the original abstract on the ASH website.
