Proliferating CLL Cells Express Transcriptionally Compromised TP53 Protein
Samuel J, Wignall AH, Najeeb H, et al.
Key Points:
Though TP53 expression is increased, the protein is trancriptionally inactive in untreated proliferating CLL cells
Apoptosis and cell-cycle arrest increased in cells, however, following pre-treatment with doxorubicin
Increased cell death associated with enhanced TP53 expression in response to DNA damage and production of reactive oxygen species induced by doxorubicin
Implications:
- Inducing full transcriptional activities of TP53 protein in proliferating cells may represent new therapeutic approach in patients with CLL
View the original abstract on the ASH website.
