Prognostic Significance Of rs6773853 Susceptibility Locus In B-Cell Non-Hodgkin’s Lymphoma
Lee JJX, Tan GSE, Tan CH, et al.
Key Points:
rs6773853, recently identified locus between BCL6 (B-cell lymphoma protein 6) and LPP (lipoma preferred partner) genes, on chromosome 3q27 confers increased risk of diffuse large B-cell lymphoma (DLBCL)
Prognostic and clinicopathologic implications of rs6773853 status in patients with B-NHL reported
No difference in clinical and tumor characteristics of B-NHL patients with or without rs6773853 susceptibility locus
Though frequency of BCL6 translocation was similar, the presence of rs6773853 locus independently conferred poorer OS in B-NHL
Implications:
- Additional studies warranted to determine mechanisms by which rs6773853 locus impacts survival in B-NHL patients
View the original abstract on the ASH website.
