DNA Methylation Changes In Patients With Chronic Lymphocytic Leukemia Relapsing After Treatment Are Not Stochastic But Rather Selectively Affect Critical Pathways For B-Cell Physiology
Papakonstantinou N, Malousi A, Tsagiopoulou M, et al.
Key Points:
Results of DNA methylation profiling of CLL patients before treatment and relapsing after treatment with chemoimmunotherapeutic approaches reported
Overall, no difference in methylation rates before treatment and after relapse, however, significant intra-individual differences existed in most patients
DNA methylation events involved genes of critical signaling pathways including calcium, MAPK, Notch and Wnt signaling pathways
Implications:
DNA methylation events associated with relapse after treatment in CLL patients selectively affect distinct critical pathways
View the original abstract on the ASH website.
