Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients
Arruga F, Gizdic B, Serra S, et al.
Key Points:
Functional biology of deregulated NOTCH1 signaling in CLL patients investigated
Constitutive NOTCH1 signaling noted in patients with NOTCH1 mutant CLL, accompanied by higher transcription of HES1 and DTX1, the main NOTCH1 target genes, particularly in lymph-node derived CLL cells
Deregulated NOTCH 1 signaling also conferred resistance to fludarabine-induced apoptosis
Implications:
NOTCH1 signaling pathway represents attractive target for anti-cancer therapy in CLL
View the original abstract on the ASH website.
