Lenalidomide Inhibits Proliferation Of Chronic Lymphocytic Leukemia Cells Via a Cereblon/p21WAF1/Cip1-Dependent Mechanism
Fecteau J, Corral LG, Futalan D, et al.
Key Points:
Mechanism of antitumor activity of lenalidomide in CLL not fully understood
Experiments conducted to determine direct effects of lenalidomide on primary CLL cells
Lenalidomide shown to inhibit proliferation of CLL cells, accompanied by arrest of cells in G1/S phase
Effect mediated by Cereblon-induced upregulation of p21, independent of p53 activity
Implications:
Data indicated that lenalidomide has both direct and indirect anti-proliferative effects in CLL
View the original abstract on the ASH website.
