Analysis Of T Cell Receptor Repertoire Reveals Evidence For Antigen-Specific Response In CLL Lymph Nodes
Pasikowska M, Yallop D, Townsend WM, et al.
Key Points:
To study role for T cells in providing CLL cells with signals necessary for survival and expansion
PD1 expressed on 25% of CD4+ cells but only 4% of CD4+ cells expressed both PD1 and ICOS in LN section of 6 CLL patients
Significantly higher commonality in TCR CDR3 clonotypes between two matching LN samples then between any LN and its matching PB sample
6 persistent TCR CDR3 clonotypes present in all 4 LN but not in PB in samples collected from same individual one month apart
Implications:
- Investigators provide evidence that CLL LN CD4+ T cells antigen experienced and that their accumulation in CLL lymph nodes may be antigen-driven
View the original abstract on the ASH website.
