NK Cells Down-Regulation and Reversal With Lenalidomide
Riches JC, Sangaralingam A, Chaplin T, et al.
Key Points:
- 117 probes showed >2-fold decrease in expression in CLL NK cells compared to healthy donor
- 52/117 (44.4%) down-regulated probes were for interferon-inducible genes
- Lenalidomide repaired down-regulation of interferon-inducible genes by increasing expression of certain genes and significant activation of interferon α, γ, and λ as upstream regulators
- Lenalidomide down-regulated the expression of 5 genes encoding killer-cell immunoglobulin-like receptors (KIRs) in healthy NK cells, but not in CLL NK cells
Implications:
- NK cells from CLL patients have down-regulation of interferon response genes
- Lenalidomide repairs defective interferon responses in CLL NK cells, whereas in healthy NK cells it down-regulates inhibitory pathways.
View the original abstract on the ASH website.
