Transcriptional Mistargeting Of NFAT2
Märklin M, Heitmann JS, Worbs D, et al.
Key Points:
- Investigators studied significance of Ca2+/NFAT signaling pathway in B-CLL (cell lines, patient's blood samples)
- CLL cells exhibited an at least three-fold overexpression of NFAT2
- Significant amounts of NFAT2 protein had translocated to nucleus in CLL cells compared within healthy B cells where virtually all NFAT2 was in cytoplasm
- Nuclear translocation was likely calcineurin-dependent as it could be inhibited with Cyclosporin A pretreatment
Implications:
- Study results may provide Ca2+/NFAT signaling axis as potential therapeutic target in CD19+CD5+ CLL cells
View the original abstract on the ASH website.
