Lymph Node Derived CLL Cells
Buggins AGS, Pasikowska M, Walsby EJ, et al.
Key Points:
- Investigators hypothesized that lymph node (LN) CLL cells have increased antigen-presenting capacity compared to those in PB
- LN CLL cells had higher expression of markers associated with co-stimulation, antigen presentation and activation
- LN-derived CLL cells induced higher levels of T cell expression of CD69 (activation marker), HLA-DR and thymidine incorporation
- LN-CLL cells had higher expression of CD49d, CD38 and reduced CXCR4
- CLL cells migrated into extravascular compartment had similar phenotype to LN CLL cells
Implications:
- LN CLL cells have an increased capacity to activate T cells and hence promote tumor proliferation
- Findings suggest that recipro cal interactions between CLL cells and LN T cells might play important role in disease progression and transendothelial migration appears to activate CLL cells.
View the original abstract on the ASH website.
