Allogeneic HSCT Patients Receiving More RBC Transfusions Are At Increased Risk For Development Of Grade 2-4 Acute Graft-Versus-Host Disease
Cynthia R. Giver, Zahir Ali, Sheilagh Barclay et al.
Key Points:
Pre-transplant leukoreduced RBC transfusions can cause recipient immunization against minor histocompatibility antigens (miHA)
Retrospective analysis of RBC transfusion records and aGvHD data collected for 181 adult allo-HSCT patients who received their transplants
Study goal: do increased numbers of transfusions during the 30-day post-transplant period correlate with increased severity of aGvHD.
Implications:
- Authors demonstrate positive correlation between number of PRBC transfusions after allo-HSCT and severity of aGvHD.
View the original abstract on the ASH website.
