Risk Stratification In Chronic Lymphocytic Leukemia Patients With IGHV3-21 Gene Usage According To Presence Of Stereotypy and Mutations In SF3B1
Sabine J, Frank D, Katharina B et. al.
Key Points:
Study authors determine prognostic impact of IGHV3-21
IGHV3-21 associated with del(11q) (35/210, 16.7% vs. 122/1,093, 11.2%, p=0.028) and was rare in patients with trisomy 12
Noo significant difference in TTT between IGHV3-21mut vs. unmutated case
IGHV3-21mut patients had slightly longer TTT compared to IGHVunmut (5.3 years vs. 3.4 years, p=0.039)
Subset #2 patients showed almost identical TTT compared to IGHVunmut patients (3.5 vs. 3.4 years).
Implications:
- Stratify IGHV3-21 patients according to the presence of stereotypy
View the original abstract on the ASH website.
