Haploidentical Peripheral Blood Stem Cell Transplantation Using Non-Myeloablative Conditioning With Post-Transplant Cyclophosphamide Regimen Is Safe and Is Associated With Very Encouraging Post-Transplant Outcomes
Pavan K, John F, Keith S et al.
Key Points:
For patients who need an allo-HSCT but do not have matched donor, transplantation of stem cell from haploidentical donor potential alternative.
Cytoxan (high dose)(HDC) in post-transplant period significantly improved outcomes of patients undergoing haploidentical transplantation.
18 patients underwent haploidentical transplant with post-transplant HDC with G-CSF mobilized PBSC as source of donor stem cells.
Implications:
- Haploidentical donor stem cell transplantation followed by HDC effective is safe and has low rates of aGvHD and cGvHD and associated with fast engraftment.
View the original abstract on the ASH website.
