Polymorphisms Of Human Leukocyte Antigen-G Gene and Clinical Outcome Of Patients With Chronic Lymphocytic Leukemia
Gabriela K, Grzybowska-Izydorczyk O, Borowiec M et al.
Key Points:
Role of polymorphism of HLA-G (HLA-G-725 and HLA-G 14bp del/ins 3’UTR)in susceptibility to CLL and clinical course of the CLL.
Identified HLA-G diplotype-based risk groups.
Patients with LR diplotypes have higher 3-years treatment free survival (TFS) (56.7%, 95% CI)
Patients with HR diplotypes have TFS (38.6%, 95% CI 27-52; p= 0.005).
Implications:
Potential role of HLA-G and its polymorphisms in CLL progression and outcome evaluated.
CLL cells might change expression of HLA-G antigen to escape of immuno-surveillance of host.
View the original abstract on the ASH website.
