Reconstructing a Genotype-Phenotype Map In Chronic Lymphocytic Leukemia
Dylan Kotliar, Dan-Avi Landau, Oren Litvin et al.
Key Points:
- Gene expression can act as intermediate measurement linking genotype to phenotype.
- Methods developed to statistically assess associations between somatic mutations, transcriptional programs, and clinical outcome.
- Associated IGHV-mutation status and 7 recurrent somatic alterations with 44 modules of co-expressed genes and later tried to understand function of modules
- Linked module expression with a clinical outcome.
Implications:
- Proof of principle for a "genotype-phenotype map."
View the original abstract on the ASH website.
