Analysis Of Gene Expression Profile in SUDHL6 Cells Of siRNA-Mediated BCL11A Downregulation
Wu H, Dongmei H, Li D et al.
Key Points:
B-cell chronic lymphocytic leukemia (CLL)/lymphoma 11A gene (BCL11A) associated with hematopoietic malignancies, precise function unknown.
659 genes differentially expressed between BCL11A knockout and control cells. Among these, 294 upregulated and 365 downregulated.
These differentially expression genes found to be involved in various signaling pathways including MAPK signaling, cell cycle, JAK-STAT signaling, TGF-beta signaling and BCR signaling pathways.
In BCL11A knockout cells, among apoptosis-related genes in BCL-2 family, BCL2L11 upregulated by 7.24-fold, and BCL-2 downregulated by 3.23-fold.
Implications:
- BCL11A involved in gene networks with cancer related functions.
View the original abstract on the ASH website.
