CXCR4 Upregulation Is a Biomarker Of Sensitivity To Targeted Inhibition Of B-Cell Receptor Signaling In Diffuse Large B-Cell Lymphoma
Chen L, Hao Y, Ouyang J et al.
Key Points:
Identified biomarkers of intact BCR signaling in DLBCLs with low or high baseline NF-κB.
Significant upregulation of CXCR4 in all BCR-dependent DLBCLs.
Chemical SYK inhibition -- all BCR-dependent DLBCLs exhibited significantly increased migration toward the CXCR4 ligand, SDF-1α, whereas the BCR-independent OxPhos DLBCLs unaffected.
Implications:
- BCR-dependent DLBCLs with low or high baseline NF-kB, SYK/PI3K inhibition associated with significant and functionally relevant upregulation of CXCR4.
View the original abstract on the ASH website.
