Favorable T Cell Reconstitution In Reduced Intensity Conditioned Allogeneic Stem Cell Transplantation with Low-Dose Rabbit Anti-Thymocyte Globulin and Total Body Irradiation
Thorn R, Meier J, Wang E et al.
Key Points:
Randomized phase II clinical trial evaluating two doses of rabbit ATG 5.1 (ATG5) and 7.5 mg/kg (ATG7.5) administered along with 450 cGy total body radiation (TBI).
Patients with hematologic malignancies conditioned with ATG-TBI.
ATG5 had 10/19 URD recipients compared to 12/22 ATG7.5.
After stem cell infusion, engraftment occurred at median of 12 days in both groups.
No difference in survival (2-year survival rates were 64% (95%CI: 61%, 67%) ATG5 and 54% (95%CI: 50%, 58%) ATG7.5.
Grade III-IV acute GVHD not observed.
Implications:
- ATG5 in combination with low dose TBI yields optimal T cell engraftment and may be useful platform for adoptive immunotherapy.
View the original abstract on the ASH website.
